Synthesis of N-(phenylsulfonyl)-CI, N-((tert-butyloxy) carbonyl)-CI, CI-CDPI1, and CI-CDPI2: CC-1065 functional analog incorporating the parent 1, 2, 7, 71- …

DL Boger, RJ Wysocki Jr, T Ishizaki

Index: Boger, Dale L.; Wysocki Jr., Ronald J.; Ishizaki, Takayoshi Journal of the American Chemical Society, 1990 , vol. 112, # 13 p. 5230 - 5240

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Citation Number: 3

Abstract

Abstract: Full details of the synthesis of N-(phenylsulfonyl)-and N-((fert-butyloxy) carbonyl)-I, 2, 7, 7a-tetrahydrocyclo-prop [1, 2-c] indol-4-one [N-(phenylsulfonyl)-CI (9) and N-BOC-CI (lo)] constituting stable derivatives of the parent cyclopropylcyclohexadienone ring system of the CC-1065 left-hand subunit are described. The resolution of an immediate CI synthetic precursor,(+)-and (-)-la, and the incorporation of (A)-,(+)-, and (-)-17b into the synthesis of ...