Synthesis of nucleosides of uronic acids V. Synthesis and antivirus activity of nucleosides of D-xyluronic acid

VA Timoshchuk, LN Kulinkovich, TI Olimpieva…

Index: Timoshchuk, V. A.; Kulinkovich, L. N.; Olimpieva, T. I.; Boreko, E. I.; Vladyko, G. V. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 1 p. 41 - 49 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 1 p. 49 - 57

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Abstract

The aim of the present research was to develop methods for the synthesis of nucleosides of xyluronic acid and to study their antivirus activity. It is known that xylofuranosyl nucleosides have appreciable anticancer and antivirus activity [i, 13, 16]. The most preferred and general method for the synthesis of nucleosides with a BD-xylo configuration is glycosylation of heterocyclic bases by the corresponding derivatives of D-xylofurano e [2, I0, 13, 16]. In the synthesis of nucleosides of D-xyluronic ...