DABCO??Mediated [4+ 2] Annulation of But??3??yn??2??one and Activated Ketones: Facile Preparation of 2, 3??Dihydropyran??4??one

Z Lian, QY Zhao, Y Wei, M Shi

Index: Lian, Zhong; Zhao, Qian-Yi; Wei, Yin; Shi, Min European Journal of Organic Chemistry, 2012 , # 17 p. 3338 - 3341

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Abstract

Abstract We found that nitrogen-containing Lewis base mediated [4+ 2] annulation of but-3- yn-2-one with activated ketones could proceed efficiently to give the corresponding 2, 3- dihydropyran-4-ones in moderate to good yields under mild conditions. The substrate scope has been carefully examined. Moreover, a plausible reaction mechanism for the [4+ 2] annulation of but-3-yn-2-one with activated ketones mediated by DABCO has been ...