Heterocyclic compound studies. II. Synthesis of 1, 4??benzodioxin, 1, 4??benzoxathiin, 1, 4??benzoxazine and 1, 4??benzothiazine derivatives

S Cabiddu, C Floris, S Melis, F Sotgiu…

Index: Cabiddu; Floris; Melis; Sotgiu Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 6 p. 1815 - 1820

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Citation Number: 28

Abstract

Abstract Benzocondensed six-membered heterocyclic rings containing two heteroatoms have been synthesized by a generally applicable method starting from disubstituted benzene compounds and methyl 4-chlorobutynoate (1) or methyl 4-bromobutenoate (2). The reactions with 1 yield a mixture of endo and exo (E or Z) isomers. The 13 C nmr spectroscopy was used to assign the structure of the synthesized compounds.