Synthesis and uptake of nitric oxide-releasing drugs by the P2 nucleoside transporter in Trypanosoma equiperdum

L Soulere, P Hoffmann, F Bringaud, J Périé

Index: Soulere, Laurent; Hoffmann, Pascal; Bringaud, Frederic; Perie, Jacques Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 12 p. 1347 - 1350

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Citation Number: 13

Abstract

A series of S-nitrosothiols, structurally related to the NO-donor S-nitroso-N- acetylpenicillamine, and of organic nitrate esters that contain amidine groups which specify a recognition via the trypanosomal purine transporter P2, were synthesized and tested for their ability to inhibit the uptake of [2-3H] adenosine on Trypanosoma equiperdum.