The reaction of thiophene and 2, 5-dimethylthiophene with isothiocyanates in the presence of aluminum chloride in nitromethane gave rise to the formation of the N-substituted carbothioamides of thiophene-2-carboxylic and 2, 5-dimethyl-thiophne-5-carboxylic acid, respectively. Under similar conditions, 2-ethylthio-5-methylthiophene was attacked by the reagent at the carbon atom adjacent to the ethylthio group, whereas 2-phenyl-5- ...
