Reactive 5'-substituted 2', 5'-dideoxyuridine derivatives as potential inhibitors of nucleotide biosynthesis

…, RW Brockman, JA Montgomery

Index: Elliott; Pruett; Brockman; Montgomery Journal of Medicinal Chemistry, 1987 , vol. 30, # 5 p. 927 - 930

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Citation Number: 6

Abstract

5'-(Bromoacetamido)-2', 5'-dideoxyuridine (3) and derivatives (8, 10, 12, and 14) substituted at the 5-position with bromo, iodo, fluoro, and ethyl groups have been synthesized as potential inhibitors of enzymes that metabolize pyrimidine nucleosides. Also prepared were 2', 5'-dideoxyuridine derivatives (4-6) substituted at the 5'-position with 2- bromopropionamido, iodoacetamido, and 4-(fluorosulfonyl) benzamido groups. ...