ChemMedChem

Structural Studies on 4, 5??Disubstituted 2??Aminoimidazole??Based Biofilm Modulators that Suppress Bacterial Resistance to β??Lactams

…, AA Yeagley, R Su, L Peng, C Melander

Index: Su, Zhaoming; Yeagley, Andrew A.; Su, Rui; Peng, Lingling; Melander, Christian ChemMedChem, 2012 , vol. 7, # 11 p. 2030 - 2039

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Citation Number: 13

Abstract

Abstract A library of 4, 5-disubstituted 2-aminoimidazole triazole amide (2-AITA) conjugates has been successfully assembled. Upon biological screening, this class of small molecules was discovered as enhanced biofilm regulators through non-microbicidal mechanisms against methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Acinetobacter baumannii (MDRAB), with active concentrations in the low micromolar ...