Synthesis of New Tacrine Analogues from 4??Amino??1H??pyrrole??3??carbonitrile

AM Salaheldin, AMF Oliveira??Campos…

Index: Salaheldin, Abdellatif M.; Oliveira-Campos, Ana M. F.; Parpot, Pier; Rodrigues, Ligia M.; Oliveira, M. Manuel; Feixoto, Francisco P. Helvetica Chimica Acta, 2010 , vol. 93, # 2 p. 242 - 248

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Citation Number: 6

Abstract

Abstract An easy preparation of 4-amino-1H-pyrrole-3-carbonitrile derivatives and their transformation into new substituted pyrrolo [3, 2-b] pyridines is described. The one-step transformation was carried out via Friedländer reaction under microwave irradiation and by classical heating methods. The use of microwave irradiation led to high conversion and shorter reaction times.