The synthesis of Sa-halogen derivatives of hydrocortisone and cortisone from 11-epi- hydrocortisone is described. Although originally intended as intermediates in a synthesis of hydrocortisone from its lla-epimer the main significance of these substances derives from their unusual biological properties The most potent compound, Sa-fluorohydrocortisone acetate, is obtained in an over-all yield of 26%. The preparation of Sa-halogenated ...
