Synlett

A Synthesis-Driven Structure Revision of 'Plagiochin E', a Highly Bioactive Bisbibenzyl

…, J Zapp, A Schaumlöffel, M Knauer, G Bringmann

Index: Speicher, Andreas; Groh, Matthias; Zapp, Josef; Schaumloeffel, Anu; Knauer, Michael; Bringmann, Gerhard Synlett, 2009 , # 11 p. 1852 - 1858

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Citation Number: 11

Abstract

Abstract Recently, a bisbibenzyl named plagiochin E showing remarkable antifungal and antitumor activities was isolated from Marchantia polymorpha, a liverwort. The total synthesis of the proposed structure for plagiochin E and of two structurally and biosynthetically related bisbibenzyls and comparison of the NMR data of the synthetic compounds with those of the isolated bisbibenzyls necessitates a structure revision for plagiochin E. Exemplarily for this ...