e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Tetrahedron
Halogenation regioselective en serie aromatique—I: Chloration des phenols et de leurs ethers a l'aide de reactifs mettant en jeu des interactions donneur-accepteur
An efficient regiospecific route for the chlorination of phenol involving hexachlorocyclohexadienones is described. The selectivity is attained by using a reagent tailored in such a way that it is able to participate in charge transfer interactions and hydrogen bonding with the substrate. This recognition between substrate (phenol) and 2, 3, 4, 4, 5, 6-hexachlorocyclohexa 2, 5-dien 1-one 1 which we have called “réactif p” allows ...
