Mimics of transaminase enzymes

…, R Leppkes, J Winkler, S Zimmerman

Index: Breslow, R.; Czarnik, A. W.; Lauer, M.; Leppkes, R.; Winkler, J.; Zimmerman, S. Journal of the American Chemical Society, 1986 , vol. 108, # 8 p. 1969 - 1979

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Citation Number: 134

Abstract

Abstract: Pyridoxamine has been attached to the primary side and to the secondary side of P- cyclodextrin; the resulting compounds convert a-keto acids to amino acids with substrate selectivity and some stereoselectivity. Pyridoxamine has also been attached to a synthetic macrocycle; the attached binding group showed substrate selectivity. Chains carrying catalytic basic groups have been attached to pyridoxamine; appropriate systems catalyze ...