Antineoplastic agents: XI. N-Bis (2-bromoethyl) amines

GR Pettit, MR Chamberland…

Index: Pettit,G.R. et al. Canadian Journal of Chemistry, 1964 , vol. 42, p. 1699 - 1706

Full Text: HTML

Citation Number: 11

Abstract

A novel halogen exchange reaction was found to accompany condensation of an acyl chloride with N-bis (2-bromoethyl) amine. Reaction between an acyl bromide and N-bis (2- bromoethyl) amine, however, gave the expected N-bis (2-bromoethyl) amide. A number of N- alkyl-N-bis (2-bromoethyl) amines were prepared by lithium aluminum hydride reduction of the corresponding N-bis (2-bromoethyl) amides. The overall transformation from N-bis (2- ...