Acta Chem. Scand. B

Synthesis of Some 4-Aminoalkyl-5-methyl-3-isoxazolols Structurally Related to Muscimol and y-Aminohutyric Acid (GABA)

H HJEDS, P KROGSGAARD-LARSEN

Index: Hjeds; Krogsgaard Larsen Acta Chemica Scandinavica, 1976 , vol. 30, # 6 B p. 567 - 573

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Citation Number: 15

Abstract

The synthesis of 4-(2-aminoethy1)-5-methyl~ 3-isoxazolol zwitterion (16a) and 4-(2- aminopropyl)-5-methyl-3-isoxazolol zwitterion (16b) which are structural analogues of 5- aminomethyl~ 3-isoxazolol (Muscimol) and of y-aminobutyric acid (GABA) is described. The