e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Studies on griseolic acid derivatives. V. Synthesis and phosphodiesterase inhibitory activity of substituted derivatives of the hydroxy group at the 2'-or 7'-position in …
Y MUROFUSHI, M KIMURA, Y IIJIMA…
Index: Murofushi; Kimura; Iijima; Yamazaki; Kaneko Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 11 p. 4442 - 4453
Substituted derivatives of the hydroxy group at the 2'-or 7'-position in griseolic acid (1) were synthesized by selective substitution in order to study the relationship between structure and inhibitory activity against adenosine 3', 5'-cyclic monophosphate (cAMP) or guanosine 3', 5'- cyclic monophosphate (cGMP) phosphodiesterase (PDE). All of the derivatives which had a configurationally inverted substituent at the 2'-position instead of the hydroxy group were ...
