An efficient two-step total synthesis of the quaterpyridine nemertelline

…, AS Voisin, A Robic, JC Lancelot, V Collot…

Index: Bouillon, Alexandre; Voisin, Anne Sophie; Robic, Audrey; Lancelot, Jean-Charles; Collot, Valerie; Rault, Sylvain Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10178 - 10180

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Citation Number: 46

Abstract

Regioselective and univocal Suzuki cross-coupling reactions performed on halopyridinyl boronic acids provide a flexible and versatile route to a multigram scale synthesis of 2, 2'- dichloro-3, 4'-bipyridine 14, which allows couplings with excess pyridin-3-yl boronic acid to give a new and efficient two-step rapid synthesis of nemertelline, the quaterpyridine neurotoxin isolated from a Hoplonemertine sea worm.