e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Bacterial translation inhibitors, 1-acylindazol-3-ols as anthranilic acid mimics
C Stiff, DR Graber, A Thorarensen, BD Wakefield…
Index: Stiff, Cory; Graber, David R.; Thorarensen, Atli; Wakefield, Brian D.; Marotti, Keith R.; Melchior, Earline P.; Sweeney, Michael T.; Han, Fusen; Rohrer, Douglas C.; Zurenko, Gary E.; Romero, Donna L. Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 23 p. 6293 - 6297
The discovery and initial optimization of a novel anthranilic acid derived class of antibacterial agents has been described in a recent series of papers. This paper describes the discovery of 1-acylindazol-3-ols as a novel bioisostere of an anthranilic acid. The synthesis and structure–activity relationships of the indazol bioisosteres are described herein.
