A Simple One??Pot Synthesis of New Imidazol??2??yl??1H??quinolin??2??ones from the Direct Reaction of 2??Chloroquinolin??3??carbaldehyde with Aromatic o??Diamines

…, P Cuervo, B Insuasty, J Quiroga, A Ortíz…

Index: Abonia, Rodrigo; Castillo, Juan; Cuervo, Paola; Insuasty, Braulio; Quiroga, Jairo; Ortiz, Alejandro; Nogueras, Manuel; Cobo, Justo European Journal of Organic Chemistry, 2010 , # 2 p. 317 - 325

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Citation Number: 6

Abstract

Abstract An alternative and general one-pot synthesis of a library of novel imidazol-2-yl-1H- quinolin-2-one derivatives was performed in 70% aqueous acetic acid by the direct reaction of 2-chloroquinolin-3-carbaldehyde with aromatic o-diamines. Experiments showed that adding Amberlyst®-15 (20% w/w) to the reaction media increased both the speed of reaction as well as the yield of products. Both DFT theoretical calculations and X-ray diffraction ...