Thioesters for the in vitro evaluation of agents to image brain cholinesterases

…, CT Jollymore, GA Reid, IR Pottie, E Martin…

Index: Macdonald, Ian R.; Jollymore, Courtney T.; Reid, G. Andrew; Pottie, Ian R.; Martin, Earl; Darvesh, Sultan Journal of Enzyme Inhibition and Medicinal Chemistry, 2013 , vol. 28, # 3 p. 447 - 455

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Abstract

Cholinesterases are associated with pathology characteristic of conditions such as Alzheimer's disease and are therefore, considered targets for neuroimaging. Ester derivatives of N-methylpiperidinol are promising potential imaging agents; however, methodology is lacking for evaluating these compounds in vitro. Here, we report the synthesis and evaluation of a series of N-methylpiperidinyl thioesters, possessing ...