Recently we reported on conceptually new enzymatically activated cyclo Sal-pronucleotides. Now, we developed this concept further with new compounds of this type. The basic idea is fast intracellular cleavage of a functionalized group at the cyclo Sal residue that results in a rapid delivery of the nucleotide and thus an intracellular enrichment of the nucleotide. The introduction of a higher alkylated acylal group, the di-iso-butyryloxymethyl group, to the ...
![6-tert-butyl-2,2-dimethyl-4H-benzo[1,3]dioxine-8-carbaldehyde Structure](https://image.chemsrc.com/caspic/262/367965-69-3.png)
