Inactivation of. gamma.-aminobutyric acid aminotransferase by (S, E)-4-amino-5-fluoropent-2-enoic acid and effect on the enzyme of (E)-3-(1-aminocyclopropyl)-2- …

RB Silverman, BJ Invergo, J Mathew

Index: Silverman, Richard B.; Invergo, Benedict J.; Mathew, Jacob Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1840 - 1846

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Citation Number: 18

Abstract

13 was shown to be a mechanism-based inactivator of y-Abu-T, ll and its mechanism of inactivation was investigated. 12 Furthermore, it was shown to be a potent in vivo inactivator with reasonable specificity for y-Abu-T; 13J4 however, in one test, it did not show an anticonvulsant effect.