New azoles with potent antifungal activity: design, synthesis and molecular docking

…, C Sheng, W Wang, Y Cao, Y Xu, H Ji, G Dong…

Index: Che, Xiaoying; Sheng, Chunquan; Wang, Wenya; Cao, Yongbing; Xu, Yulan; Ji, Haitao; Dong, Guoqiang; Miao, Zhenyuan; Yao, Jianzhong; Zhang, Wannian European Journal of Medicinal Chemistry, 2009 , vol. 44, # 10 p. 4218 - 4226

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Citation Number: 38

Abstract

In response to the urgent need for novel antifungal agents with improved activity and broader spectrum, computer modeling was used to rational design novel antifungal azoles. On the basis of the active site of lanosterol 14α-demethylase from Candida albicans (CACYP51), a series of new azoles with substituted-phenoxypropyl piperazine side chains were rational designed and synthesized. In vitro antifungal activity assay indicates that the ...