Medicinal Chemistry Research

Synthesis, characterization and biological activity of some new carbostyril bearing 1H-pyrazole moiety

NJ Thumar, MP Patel

Index: Thumar, Nilesh J.; Patel, Manish P. Medicinal Chemistry Research, 2012 , vol. 21, # 8 p. 1751 - 1761

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Citation Number: 13

Abstract

Abstract In this study, 16 new 4-pyrazolyl-N-arylquinoline-2, 5-dione 4 have been synthesized by the multicomponent reaction of pyrazole-4-carbaldehyde 1, Meldrum's acid 2 and 3-aryl-5, 5-disubstitutedcyclohex-2-enone 3. The structures of compounds 4 were established by the combined use of 1 H NMR, 13 C NMR, FT-IR and mass spectra. All the 16 compounds were tested in vitro for their bacterial and fungal activity against a list of ...