Synlett

Selective N-benzylation of amino acids under homogeneously catalyzed hydrogenation conditions

VI Tararov, R Kadyrov, C Fischer, A Börner

Index: Tararov, Vitali I.; Kadyrov, Renat; Fischer, Christine; Boerner, Armin Synlett, 2004 , # 11 p. 1961 - 1962

Full Text: HTML

Citation Number: 2

Abstract

N-Benzyl amino acids find applications in peptide synthesis and are valuable building blocks for the synthesis of chiral compounds. [1] Commonly, they are prepared by N-alkylation of amino acids with benzyl halogenides. [2] However, this method may fail when additional functional groups like HO-functionalities are present in the molecule. As an alternative, the reductive amination with benzaldehyde employing complex borohydrides as hydrogen source was ...