Synthesis and the crystal structures of N-(2-nitroxyethyl) isonicotinamide and its complexes with PdCl2 and PtCl2 as potential antitumor medicines

…, MA Fadeev, GV Strukov, VV Kedrov, GV Shilov…

Index: Fedorov; Golovina; Fadeev; Strukov; Kedrov; Shilov; Boiko; Atovmyan Russian Chemical Bulletin, 2001 , vol. 50, # 3 p. 520 - 524

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Citation Number: 3

Abstract

Abstract Previously unknown N-(2-nitroxyethyl) isonicotinamide was synthesized by the reaction of isonicotinoyl chloride with 2-nitroxyethylamine and was used as a ligand in the reactions with PdCl 2 and PtCl 2 to prepare new complexes, viz., trans-bis [(2-nitroxyethyl) isonicotinamide-N] dichloropalladium (ii) and cis-bis [(2-nitroxyethyl) isonicotinamide-N] dichloroplatinum (ii), respectively. The structures of the ligand and the resulting complexes ...