Synthesis of specifically deuterium labeled sulfur and oxygen ether side-chain-extended antileukemic (2-chloroethyl) nitrosoureas and study of their products and …

…, R Rao Koganty, AV Joshua

Index: Lown, J. William; Koganty, R. Rao; Joshua, Alummoottil V. Journal of Organic Chemistry, 1982 , vol. 47, # 11 p. 2027 - 2033

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Citation Number: 14

Abstract

The synthesis of certain specifically deuterium labeled ether and thioether side-chain- extended (2-chloroethy1) nitrosoureas is described. Controlled aqueous decomposition of a- d2-S-CENU and@-d2-S-CENU under physiological conditions affords six products including 2-chloroethyl vinyl ether, bis (2-chloroethyl) thioether, and 1, 2-dihydrothiophenes. The reactions, which are dominated by elimination under these conditions, the products, and ...