A novel, efficient, microwave assisted route for the synthesis of 6-substituted-2, 3, 4- trihydropyrimido [1, 2-c]-9, 10, 11, 12-tetrahydrobenzo [b] thieno [3, 2-e] pyrimidines in good yields has been developed. The intermediates, 2-substituted-4-[3-hydroxy (propyl-1-amino)]