Efficient microwave combinatorial synthesis of novel indolic arylpiperazine derivatives as serotoninergic ligands

F Frecentese, F Fiorino, E Perissutti, B Severino…

Index: Frecentese, Francesco; Fiorino, Ferdinando; Perissutti, Elisa; Severino, Beatrice; Magli, Elisa; Esposito, Antonella; De Angelis, Francesca; Massarelli, Paola; Nencini, Cristina; Viti, Barbara; Santagada, Vincenzo; Caliendo, Giuseppe European Journal of Medicinal Chemistry, 2010 , vol. 45, # 2 p. 752 - 759

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Citation Number: 12

Abstract

An easy and convenient microwave-assisted synthesis of a small library of indolic arylpiperazine derivatives is described. Parallel and mixed pool combinatorial methods are reported and compared. The described reactions are nucleophilic substitutions of several aromatic piperazines in presence of K2CO3. Good yields and short reaction times are the main aspect of these procedures. Binding assays shed additional light on the influence of ...