Selection and development of the manufacturing route for EP1 antagonist GSK269984B

M Whiting, K Harwood, F Hossner…

Index: Organic Process Research and Development, , vol. 14, # 4 p. 820 - 831

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Citation Number: 12

Abstract

... Organic Process Research & Development. ... Org. Process Res ... Within these, the Friedel−Crafts route (B) was deprioritised, due to its requirement for a high-temperature plant, and other processing concerns.(24) The aldol Route C and the dibromopyridine Route D were very close ...