Annelated piperazinyl??7, 8??dihydro??6H??thiopyrano [3, 2??d] pyrimidines

…, M MacCoss, TJ Ikeler, J Hirshfield…

Index: Wu; MacCoss; Ikeler; Hirshfield; Arison; Tolman Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 6 p. 1559 - 1563

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Citation Number: 9

Abstract

Abstract Tricyclic analogs of piperazinylthiopyrano [3, 2-d] pyrimidine hypoglycemic agents were prepared. The angular tricyclic systems, 8, 9-dihydro-7H-thiopyrano [2, 3-e][1, 2, 4] triazolo [4, 3-a] pyrimidine and 8, 9-dihydro-7H-tetrazolo [1, 5-a] thiopyrano [2, 3-e] pyrimidine derivatives were synthesized from 2, 4-dichloro-7, 8-dihydro-6H-thiopyrano [3, 2- d] pyrimidine in three step sequences. Derivatives of the linear tricyclic system, 5, 6- ...