Facile and efficient generation of quinolone amides from esters using aluminum chloride

MK Schwaebe, DM Ryckman, JY Nagasawa, F Pierre…

Index: Schwaebe, Michael K.; Ryckman, David M.; Nagasawa, Johnny Y.; Pierre, Fabrice; Vialettes, Anne; Haddach, Mustapha Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1096 - 1100

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Citation Number: 5

Abstract

Quinolones have a long and rich history as chemotherapeutic antibacterial agents that eradicate bacteria by interfering with DNA replication, transcription, and repair. 1 Their broad spectrum activity results from the inhibition of bacterial DNA gyrase and topoisomerase IV. 2 Certain sub-classes of quinolones have also been reported to be active against cancer cells by means of inhibiting human Topoisomerases I and II. 3 We have recently discovered a new class ...