Synthesis and some transformations of 2-(3-amino-1-phenylpropyl) furan

…, GA Gevorgyan, GM Snkhchyan, GA Panosyan

Index: Arutyunyan; Akopyan; Gevorgyan; Snkhchyan; Panosyan Chemistry of Heterocyclic Compounds, 2005 , vol. 41, # 4 p. 437 - 441

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Abstract

Abstract A preparative method was developed for the synthesis of ethyl furfurylidenecyanoacetate. Its condensation with phenylmagnesium bromide gave ethyl α- cyano-β-(2-furyl) hydrocinnamate, the decarboxylation of which led to β-(2-furyl) hydrocinnamonitrile. Reduction of this nitrile with lithium aluminum hydride gave 2-(3-amino- 1-phenylpropyl) furan. Some of its transformations were studied.