Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA: Protein N??myristoyltransferase

GQ Zheng, X Hu, JM Cassady, LA Paige…

Index: Zheng; Hu; Cassady; Paige; Geahlen Journal of Pharmaceutical Sciences, 1994 , vol. 83, # 2 p. 233 - 238

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Citation Number: 13

Abstract

Abstract To develop inhibitors of myristoyl CoA: protein N-myristoyltransferase (NMT), a series of myristoyl coenzyme A analogues and myristoyl peptides were synthesized, including S-(2-oxopentadecyl)-CoA (1), S-(2-hydroxypentadecyl)-CoA (2), S-(2- oxopentadecyl)-pantetheine (3), Myr-N-Gly-(L)-Phe (4), Myr-NGly-(L)-Tyr (5), and Myr-N-Gly- (L)-Asn-Ala-Ala-Ser-Ala-Arg-(NH 2)(6). Biological evaluation of these compounds in an in ...