The Journal of Organic chemistry

A practical and efficient method for the synthesis of. beta.-lactones

RL Danheiser, JS Nowick

Index: Danheiser, Rick L.; Nowick, James S. Journal of Organic Chemistry, 1991 , vol. 56, # 3 p. 1176 - 1185

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Citation Number: 96

Abstract

This paper describes a convenient one-step preparation of@-lactones based on the addition of thiol ester enolates to carbonyl compounds. Under the proper conditions the resulting aldolates undergo spontaneous cyclization to produce 8-lactones in good to excellent yield. The new 0-lactone synthesis provides access to 2-oxetanones with a variety of substituents and substitution patterns. In general, thiol ester enolates combine with carbonyl ...