Tetrahedron

Chemoenzymatic synthesis of deoxy analogues of the DNA topoisomerase II inhibitor eleutherin and the 3C-protease inhibitor thysanone

P Bachu, J Sperry, MA Brimble

Index: Bachu, Prabhakar; Sperry, Jonathan; Brimble, Margaret A. Tetrahedron, 2008 , vol. 64, # 21 p. 4827 - 4834

Full Text: HTML

Citation Number: 22

Abstract

The pyranonaphthoquinone family of antibiotics is isolated from plants, fungi and aphid pigments and has been shown to exhibit activity against various Gram-positive bacteria, pathogenic fungi and yeasts, as well as antiviral activity. 1, 1a and 1b This class of compounds has been postulated to act as bioreductive alkylating agents and hence is important structural leads for cancer therapy. 2 Monomeric members of the pyranonaphthoquinone family that contain a 1,3- ...