Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)-and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4- …

T Tuccinardi, A Martinelli, E Nuti, P Carelli…

Index: Bioorganic and Medicinal Chemistry, , vol. 14, # 12 p. 4260 - 4276

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Citation Number: 65

Abstract

... Bioorganic & Medicinal Chemistry. ... possessing a selective inhibitory activity on MMPs that are over-expressed in tumours are in great demand, with particular reference to viability control and invasiveness of the cancer cell, and many groups and pharmaceutical companies all ...