Abstract DMA, DOB and PMA are increasingly abused central nervous system stimulants with neurotoxic properties. In recent years, many controlled substance analogs (designer drugs) with a large variety of structures have reached the illegal market, making their identification difficult. Therefore, this work studies the synthesis of DOB-d 6, DMA-d 6 and PMA-d 3 as internal standards for use in gas chromatography-mass spectrometry (GC-MS ...