Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT2c receptors

…, JB Mandeville, JM Hooker

Index: Hooker, Jacob M.; Schoenberger, Matthias; Schieferstein, Hanno; Fowler, Joanna S. Angewandte Chemie - International Edition, 2008 , vol. 47, # 32 p. 5989 - 5992

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Citation Number: 8

Abstract

The serotonin 5-HT2c receptor is implicated in a number of diseases including obesity, depression, anxiety, and schizophrenia. In order to ascribe the role of 5-HT2c in these diseases, a method for measuring 5-HT2c density and function in vivo, such as with positron