A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells

…, H Uchiyama, T Ohura, H Sakakibara, R Kuruto…

Index: Takemura, Hitomi; Uchiyama, Harue; Ohura, Takeshi; Sakakibara, Hiroyuki; Kuruto, Ryoko; Amagai, Takashi; Shimoi, Kayoko Journal of Steroid Biochemistry and Molecular Biology, 2010 , vol. 118, # 1-2 p. 70 - 76

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Citation Number: 17

Abstract

A 17β-estradiol (E2) is hydrolyzed to 2-hydroxy-E2 (2-OHE2) and 4-hydroxy-E2 (4-OHE2) via cytochrome P450 (CYP) 1A1 and 1B1, respectively. In estrogen target tissues including the mammary gland, ovaries, and uterus, CYP1B1 is highly expressed, and 4-OHE2 is predominantly formed in cancerous tissues. In this study, we investigated the inhibitory effects of chrysoeriol (luteorin-3′-methoxy ether), which is a natural methoxyflavonoid, ...