The kinetics of the concurrent hydrolysis and intramolecular aminolysis of y-ethyl glutamate have been studied in aqueous solution (40" C) in the range of pH 7.6-10.4. While hydrolysis contributes only 3% to the overall rate of reaction of y-ethyl glutamate at pH 10.4, its importance relative to aminolysis increases with decreasing pH; at pH 8, the hydrolysis pathway accounts for 32% of the rate of disappearance of the ester. The pH-rate profile for ...
