Abstract The first synthesis of both enantiomers of 6, 7-dimethoxy-1, 2, 3, 4- tetrahydroisoquinoline-1-carboxylic acid was accomplished through dynamic kinetic resolution in procedures based on CAL-B-or subtilisin Carlsberg-catalysed enantioselective hydrolysis of the corresponding ethyl esters in aqueous NH 4 OAc buffer at pH 8.5. The products were obtained with high enantiopurity (92–93% ee) in good yields (85–92%).(R)- ...
