Steroids

Stereoselective synthesis of some methyl-substituted steroid hormones and their in vitro cytotoxic activity against human gastric cancer cell line MGC-803

C Li, W Qiu, Z Yang, J Luo, F Yang, M Liu, J Xie, J Tang

Index: Li, Chun; Qiu, Wenwei; Yang, Zhengfeng; Luo, Jian; Yang, Fan; Liu, Mingyao; Xie, Juan; Tang, Jie Steroids, 2010 , vol. 75, # 12 p. 859 - 869

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Citation Number: 20

Abstract

A series of 3-, 7-, 15-, and 16-methyl-substituted steroid analogs were synthesized via a highly stereoselective 1, 6-conjugate addition. Under the catalysis of CuBr, AlMe3 reacted with four steroid dienone precursors to afford either the corresponding α-epimer of C-3 and C-7 methyl-substituted steroids as the major products, and the ratio of α/β was up to 10/1. No β-epimer has been detected for methyl addition at C-16. However, under the same ...