A novel 99m Tc-labeled testosterone derivative as a potential agent for targeting androgen receptors

…, G Samuel, K Bapat, S Subramanian, MRA Pillai…

Index: Das, Tapas; Banerjee, Sharmila; Samuel, Grace; Bapat, Ketaki; Subramanian, Suresh; Pillai, Maroor R.A.; Venkatesh, Meera Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5788 - 5792

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Citation Number: 12

Abstract

With an insight that ligands possessing a N2S2 tetradentate array of donor atoms serve as ideal bifunctional chelating agents (BFCA) in the radiolabeling of target-specific agents, 5- hydroxy-3, 7-diazanonan-1, 9-dithiol (DAHPES) with a derivatizable substituent in the form of a hydroxyl group in the backbone was synthesized. The preparation of a steroid conjugate via coupling of this BFCA with testosterone-3-(O-carboxymethyl) oxime and the ...