A Convergent General Strategy for the Functionalized 2??Aryl Cycloalkyl??Fused Chromans: Intramolecular Hetero??Diels–Alder Reactions of ortho??Quinone Methides

J Tummatorn, S Ruchirawat…

Index: Tummatorn, Jumreang; Ruchirawat, Somsak; Ploypradith, Poonsakdi Chemistry - A European Journal, 2010 , vol. 16, # 5 p. 1445 - 1448

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Citation Number: 19

Abstract

Chroman is a core structure of flavonoids, which have been shown to exhibit a wide array of biological activities.[1] Palodesangren C (1; Scheme1), a natural Diels–Alder adduct isolated from Brosimum rubescens, showed potent inhibition of the binding of 5α- dihydrotestosterone (DHT) with the androgen receptor.[2] Parvifolol A (2; Scheme 1), a natural product isolated from Gnetum parvifolium, was evaluated for the inhibitory activity ...