Xenobiotica

Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives

MV Bach, RT Coutts, GB Baker

Index: Bach, Mimi V.; Coutts; Baker Xenobiotica, 1999 , vol. 29, # 7 p. 719 - 732

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Citation Number: 69

Abstract

1. Amphetamine (AM) and five amphetamine derivatives, N-ethylamphetamine (NEA), N- butylamphetamine (NBA), 4-methoxyamphetamine (M-AM), 4-methoxy-Nethylamphetamine (M-NEA) and 4-methoxy-N-butylamphetamine (M-NBA) were incubated with microsomal preparations from cells expressing human CYP2D6 to determine whether the enzyme was capable of catalyzing the direct ring oxidation of all substrates; the N-dealkylation of NEA, ...