Abstract Maresin is a potent anti-inflammatory lipid mediator derived from docosahexaenoic acid (DHA). A highly convergent total synthesis of two proposed structures of C7-epimeric maresins from the four known fragments was achieved in 17 steps. The three key coupling reactions were the BF 3-mediated alkyne attack on the epoxide, chiral titanium complex- promoted enantioselective alkyne addition to the aldehyde, and a Julia–Kocienski ...
