The Journal of Organic Chemistry

Approach to the use of benzylpenicillin acylase for configurational correlations of amino compounds. 2. Hydrolysis of N-(p-aminophenylacetyl) derivatives of some …

D Rossi, A Calcagni, A Romeo

Index: Rossi,D. et al. Journal of Organic Chemistry, 1979 , vol. 44, # 13 p. 2222 - 2225

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Citation Number: 43

Abstract

A limitation in studying the steric course of benzylpenicillinacylase (BPA)-catalyzed hydrolyses of N-(phenylacetyllamino derivatives is the low solubility in aqueous solution. By using the more soluble N-(p-aminophenylacetyl) derivatives, the hydrolysis of some chiral primary amines (with known absolute configuration) could be examined and priority relations between the substituents at the asymmetric carbon atoms established. ...