Revisiting secondary structures in NCA polymerization: Influences on the analysis of protected polylysines

D Huesmann, A Birke, K Klinker, S Türk…

Index: Huesmann, David; Birke, Alexander; Klinker, Kristina; Tuerk, Stephan; Raeder, Hans Joachim; Barz, Matthias Macromolecules, 2014 , vol. 47, # 3 p. 928 - 936

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Citation Number: 25

Abstract

Two series (degree of polymerization: 20–200) of polylysines with Z and TFA protecting groups were synthesized, and their behavior in a range of analytical methods was investigated. Gel permeation chromatography of the smaller polypeptides reveals a bimodal distribution, which is lost in larger polymers. With the help of GPC, NMR, circular dichroism (CD), and MALDI-TOF, it was demonstrated that the bimodal distribution is not due to ...