Abstract: In an effort to gain insight on the balance of noncovalent forces that controls the adoption of folded conformations in small molecules, we have examined intramolecular hydrogen bond formation in a series of diamides containing a variety of conformational constraints. The intramolecularly hydrogen-bonded state of flexible diamide 2 was previously shown to be enthalpically favored by about 1.5 kcal/mol relative to the non- ...
